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Deconstruction - Reconstruction: Analysis of the Crucial Structural Elements of GluN2B-Selective, Negative Allosteric NMDA Receptor Modulators with 3-Benzazepine Scaffold., Ritter N, Korff M, Markus A, Schepmann D, Seebohm G, Schreiber JA, Wünsch B., Cell Physiol Biochem. March 3, 2021; 55 (S3): 1-13.
Differential Regulation of Human Serotonin Receptor Type 3A by Chanoclavine and Ergonovine., Eom S, Jung W, Lee J, Yeom HD, Lee S, Kim C, Park HD, Lee JH., Molecules. February 24, 2021; 26 (5):
Design of novel Xenopus GLP-1-based dual glucagon-like peptide 1 (GLP-1)/glucagon receptor agonists., Jiang N, Jing L, Li Q, Su S, Yang Q, Zhou F, Chen X, Han J, Tang C, Tang W., Eur J Med Chem. February 15, 2021; 212 113118.
Dual Screen for Efficacy and Toxicity Identifies HDAC Inhibitor with Distinctive Activity Spectrum for BAP1-Mutant Uveal Melanoma., Kuznetsoff JN, Owens DA, Lopez A, Rodriguez DA, Chee NT, Kurtenbach S, Bilbao D, Roberts ER, Volmar CH, Wahlestedt C, Brothers SP, Harbour JW., Mol Cancer Res. February 1, 2021; 19 (2): 215-222.
Developmental reproductive toxicity and endocrine activity of propiconazole in the Xenopus tropicalis model., Svanholm S, Säfholm M, Brande-Lavridsen N, Larsson E, Berg C., Sci Total Environ. January 20, 2021; 753 141940.
Development of Antimicrobial Stapled Peptides Based on Magainin 2 Sequence., Hirano M, Saito C, Yokoo H, Goto C, Kawano R, Misawa T, Demizu Y., Molecules. January 16, 2021; 26 (2):
Developing Tadpole Xenopus laevis as a Comparative Animal Model to Study Mycobacterium abscessus Pathogenicity., Lopez A, Shoen C, Cynamon M, Dimitrakopoulou D, Paiola M, Pavelka MS, Robert J., Int J Mol Sci. January 15, 2021; 22 (2):
Distinct roles for prominin-1 and photoreceptor cadherin in outer segment disc morphogenesis in CRISPR-altered X. laevis., Carr BJ, Stanar P, Moritz OL., J Cell Sci. January 11, 2021; 134 (1):
Derivation of proliferative islet1-positive cells during metamorphosis and wound response in Xenopus., Umezawa S, Miyakawa M, Yamaura T, Kubo H, Kinoshita T., Histochem Cell Biol. January 1, 2021; 155 (1): 133-143.
Datamining and functional environmental genomics reassess the phylogenetics and functional diversity of fungal monosaccharide transporters., Barbi F, Vallon L, Guerrero-Galán C, Zimmermann SD, Melayah D, Abrouk D, Doré J, Lemaire M, Fraissinet-Tachet L, Luis P, Marmeisse R., Appl Microbiol Biotechnol. January 1, 2021; 105 (2): 647-660.
DNA Damage Response in Xenopus laevis Cell-Free Extracts., Aparicio Casado T, Gautier J., Methods Mol Biol. January 1, 2021; 2267 103-144.
Detection of N6-Methyladenine in Eukaryotes., Liu B, Wang H., Adv Exp Med Biol. January 1, 2021; 1280 83-95.
Differential liver histopathological responses to amphibian chytrid infection., Salla RF, Jones-Costa M, Abdalla FC, Vidal FAP, Boeing GANS, Oliveira CR, Silva-Zacarin ECM, Franco-Belussi L, Rizzi-Possignolo GM, Lambertini C, Toledo LF., Dis Aquat Organ. December 17, 2020; 142 177-187.
Design, Synthesis, and Insecticidal Activity of 5,5-Disubstituted 4,5-Dihydropyrazolo[1,5-a]quinazolines as Novel Antagonists of GABA Receptors., Jiang X, Yang S, Yan Y, Lin F, Zhang L, Zhao W, Zhao C, Xu H., J Agric Food Chem. December 16, 2020; 68 (50): 15005-15014.
Design, Synthesis, and in vitro Evaluation of P2X7 Antagonists., T Pournara D, Durner A, Kritsi E, Papakostas A, Zoumpoulakis P, Nicke A, Koufaki M., ChemMedChem. December 15, 2020; 15 (24): 2530-2543.
DAAM2 Variants Cause Nephrotic Syndrome via Actin Dysregulation., Schneider R, Deutsch K, Hoeprich GJ, Marquez J, Hermle T, Braun DA, Seltzsam S, Kitzler TM, Mao Y, Buerger F, Majmundar AJ, Onuchic-Whitford AC, Kolvenbach CM, Schierbaum L, Schneider S, Halawi AA, Nakayama M, Mann N, Connaughton DM, Klämbt V, Wagner M, Riedhammer KM, Renders L, Katsura Y, Thumkeo D, Soliman NA, Mane S, Lifton RP, Shril S, Khokha MK, Hoefele J, Goode BL, Hildebrandt F., Am J Hum Genet. December 3, 2020; 107 (6): 1113-1128.
Design, synthesis and biological activities of piperidine-spirooxadiazole derivatives as α7 nicotinic receptor antagonists., Zhang H, He X, Wang X, Yu B, Zhao S, Jiao P, Jin H, Liu Z, Wang K, Zhang L, Zhang L., Eur J Med Chem. December 1, 2020; 207 112774.
Disease-associated HCN4 V759I variant is not sufficient to impair cardiac pacemaking., Erlenhardt N, Kletke O, Wohlfarth F, Komadowski MA, Clasen L, Makimoto H, Rinné S, Kelm M, Jungen C, Decher N, Meyer C, Klöcker N., Pflugers Arch. December 1, 2020; 472 (12): 1733-1742.
Dact-4 is a Xenopus laevis Spemann organizer gene related to the Dapper/Frodo antagonist of β-catenin family of proteins., Colozza G, De Robertis EM., Gene Expr Patterns. December 1, 2020; 38 119153.
Dusp1 modulates activin/smad2 mediated germ layer specification via FGF signal inhibition in Xenopus embryos., Umair Z, Kumar S, Rafiq K, Kumar V, Reman ZU, Lee SH, Kim S, Lee JY, Lee U, Kim J., Anim Cells Syst (Seoul). November 27, 2020; 24 (6): 359-370.
Dinucleosome specificity and allosteric switch of the ISW1a ATP-dependent chromatin remodeler in transcription regulation., Bhardwaj SK, Hailu SG, Olufemi L, Brahma S, Kundu S, Hota SK, Persinger J, Bartholomew B., Nat Commun. November 20, 2020; 11 (1): 5913.
DNA content contributes to nuclear size control in Xenopus laevis., Heijo H, Shimogama S, Nakano S, Miyata A, Iwao Y, Hara Y., Mol Biol Cell. November 15, 2020; 31 (24): 2703-2717.
Dissection of P2X4 and P2X7 Receptor Current Components in BV-2 Microglia., Trang M, Schmalzing G, Müller CE, Markwardt F., Int J Mol Sci. November 11, 2020; 21 (22):
De novo mutations in FBRSL1 cause a novel recognizable malformation and intellectual disability syndrome., Ufartes R, Berger H, Till K, Salinas G, Sturm M, Altmüller J, Nürnberg P, Thiele H, Funke R, Apeshiotis N, Langen H, Wollnik B, Borchers A, Pauli S., Hum Genet. November 1, 2020; 139 (11): 1363-1379.
Design, synthesis, and electrophysiological evaluation of NS6740 derivatives: Exploration of the structure-activity relationship for alpha7 nicotinic acetylcholine receptor silent activation., Pismataro MC, Horenstein NA, Stokes C, Quadri M, De Amici M, Papke RL, Dallanoce C., Eur J Med Chem. November 1, 2020; 205 112669.
Do muscle contractile properties drive differences in locomotor performance in invasive populations of Xenopus laevis in France?, Padilla P, Tallis J, Hurst J, Courant J, James RS, Herrel A., J Comp Physiol B. November 1, 2020; 190 (6): 771-778.
Dynamic expression of MMP28 during cranial morphogenesis., Gouignard N, Theveneau E, Saint-Jeannet JP., Philos Trans R Soc Lond B Biol Sci. October 12, 2020; 375 (1809): 20190559.
Defining the Specific Pathogen-Free State of Xenopus Using TaqMan Assays., Hensley CL, Bowes KM, Feldman SH., Cold Spring Harb Protoc. October 1, 2020; 2020 (10):
Developmentally-programmed cellular senescence is conserved and widespread in zebrafish., Da Silva-Álvarez S, Guerra-Varela J, Sobrido-Cameán D, Quelle A, Barreiro-Iglesias A, Sánchez L, Collado M., Aging (Albany NY). September 29, 2020; 12 (18): 17895-17901.
Diffusible GRAPHIC to visualize morphology of cells after specific cell-cell contact., Kinoshita N, Huang AJY, McHugh TJ, Miyawaki A, Shimogori T., Sci Rep. September 2, 2020; 10 (1): 14437.
Disabled-2: a positive regulator of the early differentiation of myoblasts., Shang N, Lee JTY, Huang T, Wang C, Lee TL, Mok SC, Zhao H, Chan WY., Cell Tissue Res. September 1, 2020; 381 (3): 493-508.
Disruption of Cav1.2-mediated signaling is a pathway for ketamine-induced pathology., Chen H, Vandorpe DH, Xie X, Alper SL, Zeidel ML, Yu W., Nat Commun. August 28, 2020; 11 (1): 4328.
Development of Conformationally Constrained α-RgIA Analogues as Stable Peptide Antagonists of Human α9α10 Nicotinic Acetylcholine Receptors., Zheng N, Christensen SB, Blakely A, Dowell C, Purushottam L, McIntosh JM, Chou DH., J Med Chem. August 13, 2020; 63 (15): 8380-8387.
Diversity of Parasites from Xenopus Laevis (Amphibia: Pipidae) and their Seasonal Rate of Infection in Selected Habitats in the Limpopo Province, South Africa., Mbokane EM, Theron J, Luus-Powel WJ., Helminthologia. August 5, 2020; 57 (3): 252-267.
Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback., Minchington TG, Griffiths-Jones S, Papalopulu N., Sci Rep. July 31, 2020; 10 (1): 12960.
Defective heart chamber growth and myofibrillogenesis after knockout of adprhl1 gene function by targeted disruption of the ancestral catalytic active site., Smith SJ, Towers N, Demetriou K, Mohun TJ., PLoS One. July 29, 2020; 15 (7): e0235433.
Discovery of Dihydropyrrolo[1,2-a]pyrazin-3(4H)-one-Based Second-Generation GluN2C- and GluN2D-Selective Positive Allosteric Modulators (PAMs) of the N-Methyl-d-Aspartate (NMDA) Receptor., Epplin MP, Mohan A, Harris LD, Zhu Z, Strong KL, Bacsa J, Le P, Menaldino DS, Traynelis SF, Liotta DC., J Med Chem. July 23, 2020; 63 (14): 7569-7600.
Differential Coassembly of α1-GABAARs Associated with Epileptic Encephalopathy., Hannan S, Affandi AHB, Minere M, Jones C, Goh P, Warnes G, Popp B, Trollmann R, Nizetic D, Smart TG., J Neurosci. July 15, 2020; 40 (29): 5518-5530.
Dach1 regulates neural crest migration during embryonic development., Kim YK, Lee H, Ismail T, Kim Y, Lee HS., Biochem Biophys Res Commun. July 5, 2020; 527 (4): 896-901.
Distinct pseudokinase domain conformations underlie divergent activation mechanisms among vertebrate MLKL orthologues., Davies KA, Fitzgibbon C, Young SN, Garnish SE, Yeung W, Coursier D, Birkinshaw RW, Sandow JJ, Lehmann WIL, Liang LY, Lucet IS, Chalmers JD, Patrick WM, Kannan N, Petrie EJ, Czabotar PE, Murphy JM., Nat Commun. June 19, 2020; 11 (1): 3060.
Dynamic properties of noise and Her6 levels are optimized by miR-9, allowing the decoding of the Her6 oscillator., Soto X, Biga V, Kursawe J, Lea R, Doostdar P, Thomas R, Papalopulu N., EMBO J. June 17, 2020; 39 (12): e103558.
DNA methylation dynamics underlie metamorphic gene regulation programs in Xenopus tadpole brain., Kyono Y, Raj S, Sifuentes CJ, Buisine N, Sachs L, Denver RJ., Dev Biol. June 15, 2020; 462 (2): 180-196.
Dynamic heterogeneity and non-Gaussian statistics for ganglioside GM1s and acetylcholine receptors on live cell membrane., He W, Su Y, Peng HB, Tong P., Mol Biol Cell. June 15, 2020; 31 (13): 1380-1391.
Differences in Intrinsic Tubulin Dynamic Properties Contribute to Spindle Length Control in Xenopus Species., Hirst WG, Biswas A, Mahalingan KK, Reber S., Curr Biol. June 8, 2020; 30 (11): 2184-2190.e5.
Desensitization of NMDA channels requires ligand binding to both GluN1 and GluN2 subunits to constrict the pore beside the activation gate., Chen YS, Tu YC, Lai YC, Liu E, Yang YC, Kuo CC., J Neurochem. June 1, 2020; 153 (5): 549-566.
Deorphanization of an odorant receptor revealed new bioactive components for green mirid bug Apolygus lucorum (Hemiptera: Miridae)., Khashaveh A, An X, Shan S, Xiao Y, Wang Q, Wang S, Li Z, Geng T, Gu S, Zhang Y., Pest Manag Sci. May 1, 2020; 76 (5): 1626-1638.
Design and characterization of a novel structural class of Kv1.3 inhibitors., Hendrickx LA, Dobričić V, Toplak Ž, Peigneur S, Mašič LP, Tomašič T, Tytgat J., Bioorg Chem. May 1, 2020; 98 103746.
Divergent Cl- and H+ pathways underlie transport coupling and gating in CLC exchangers and channels., Leisle L, Xu Y, Fortea E, Lee S, Galpin JD, Vien M, Ahern CA, Accardi A, Bernèche S., Elife. April 28, 2020; 9
Determining the correct stoichiometry of Kv2.1/Kv6.4 heterotetramers, functional in multiple stoichiometrical configurations., Möller L, Regnier G, Labro AJ, Blunck R, Snyders DJ., Proc Natl Acad Sci U S A. April 28, 2020; 117 (17): 9365-9376.
De novo variants in SLC12A6 cause sporadic early-onset progressive sensorimotor neuropathy., Park J, Flores BR, Scherer K, Kuepper H, Rossi M, Rupprich K, Rautenberg M, Deininger N, Weichselbaum A, Grimm A, Sturm M, Grasshoff U, Delpire E, Haack TB., J Med Genet. April 1, 2020; 57 (4): 283-288.

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